Most liver cysts do not become cancerous, but some people with a long history of liver cysts may become cancerous. Liver cysts include simple liver cysts, polycystic liver cysts, liver cysts, etc. These liver cysts are mostly benign liver diseases, and most of them will not become cancerous. However, there are some patients with liver cysts who have a long history of the disease, and the wall of the cysts is found to have developed from a smooth state to a nodular shape through imaging examination, and may be accompanied by elevated serum CA199 or 125 indicators, which may become cancerous. In addition, liver cysts in some patients may be caused by parasitic co-infections, which may lead to cholangiocarcinoma. In order to reduce the chance of cancer, once liver cysts are diagnosed, or if the cysts are increasing in size, hidden pain in the right upper abdomen, abdominal mass, enlarged liver, fullness after eating, stomach discomfort, etc., early treatment should be carried out. Most patients have a good prognosis after reasonable treatment in the early stage. Those who are in danger of cancerous changes should go to regular hospitals for diagnosis and treatment in time.