Dampness and coldness in the large intestine can be mainly manifested as cold-dampness diarrhea, and the treatment should be dispersing cold and dispelling dampness to achieve the purpose of stopping diarrhea. Cold-dampness and diarrhea can be manifested as heaviness in the head, heaviness in the limbs, stickiness in the mouth, and sticky stools. Treatment should be aromatic and dissolve dampness, relieve the epidermis and dispel cold (remove the cold from the muscle surface). The formula chooses Huo Xiang Zheng Qi San plus subtractions. In the formula, Huo Xiang detoxifies the surface and disperses cold, aromatizes and transforms dampness, Atractylodes macrocephala, Poria, Chen Pi, Semenxia strengthens the spleen and removes dampness, Hou Pu and Daji Pi regulate the qi and remove fullness, Perilla frutescens and Angelica dahurica detoxify the surface and disperses cold, and Platycodonopsis ternata declares the lungs to transform dampness. If dampness is heavy, or cold dampness is in the interior, abdominal distension and intestinal tinnitus, dysuria (unsmooth urination), white thick greasy moss, we can use Stomach Ling Soup to strengthen the spleen and dry dampness (strengthen the spleen and get rid of dampness), and dissolve the qi to promote dampness; if cold is heavier than dampness, abdominal distension and cold pain, we can use Reasoning Pill to add flavor. Patients with cold and dampness in the large intestine should pay attention to keeping warm and not staying up late. Normally, dietary care can be carried out, such as consuming more burnt rice porridge, yam and mutton porridge, tonic fat boiled pork loin, codonopsis and golden cherry seed soup, etc. The adverse reactions and contraindications of the above prescriptions are not clear. The use of Chinese medicines should be recognized by a Chinese medicine practitioner, and should not be used blindly, in order to avoid adverse consequences.