Elevated blood uric acid level is mainly due to purine metabolism disorders and uric acid excretion abnormalities, can be used to inhibit uric acid production drugs such as febuxostat, allopurinol and promote uric acid excretion drugs such as probenecid, benzbromarone and other drugs to reduce uric acid. Uric acid lowering drugs can be divided into two categories of drugs to inhibit uric acid production and promote uric acid excretion of drugs, can be different aspects to achieve the purpose of controlling the level of blood uric acid concentration, which inhibits the production of uric acid drugs, including allopurinol and febuxostat, and promote uric acid excretion of drugs, mainly including probenecid and benzbromarone. According to the patient’s specific condition, personal constitution and other factors to choose the appropriate uric acid lowering drugs, after taking the drugs, such as serious adverse drug reactions need to communicate with the physician in a timely manner. Drugs need to be used under the guidance of a physician, it is recommended that patients who need to take uric acid-lowering drugs to the rheumatology and immunology department of a regular hospital for detailed consultation.