There are many causes of cough and chest pain, including pleurisy, infectious pneumonia, lung cancer and other causes, which need to be treated differently according to different causes. 1. Pleurisy: Tuberculous pleurisy is a common cause of cough and chest pain. For treatment, active anti-tuberculosis treatment is needed, and anti-tuberculosis drugs such as isoniazid and rifampicin can be used. 2. Infectious pneumonia: active anti-infection treatment is mainly adopted, and commonly used drugs include cefmetazole, levofloxacin and other anti-infection drugs. 3. Lung cancer: some lung cancer patients may have cough with chest pain. If there are indications for surgery, surgery can be given; if there are no indications for surgery, anti-tumor treatment can be taken, which can be controlled by radiotherapy or timely use of EGFR-tyrosine kinase inhibitors such as daclatinib, targeted agent bevacizumab or combination of radiotherapy according to the situation. Cough and chest pain can also be seen in other diseases, and it is recommended to consult a doctor in time to clarify the diagnosis and standardize the treatment.