Anastomotic fistula after total gastrectomy can be treated conservatively or surgically depending on the size of the fistula. If the fistula is relatively small after total gastrectomy, conservative treatment is mainly adopted, including short-term water fasting and gastrointestinal decompression, intravenous nutrition, and also the use of antibiotics, such as amoxicillin, cefadroxil and so on, which can help to prevent infection. However, if the conservative treatment after surgery is ineffective, or the fistula is relatively large, it is often necessary to take another surgical treatment, anastomosis repair, and postoperative active anti-infection, to avoid causing sepsis. Anastomotic fistula after total gastrectomy can have a great impact on the body, must cooperate with the doctor in time for treatment.