Plateau reaction refers to the gradual decrease of oxygen partial pressure with the increase of altitude. Lack of oxygen is the main cause of plateau reaction, which will lead to dizziness, headache, weakness, nausea, vomiting, feeling of panic, chest tightness, shortness of breath when resting, and more obvious after activity, accelerated heartbeat, blue lips or nails, and purple color. Once the plateau reaction occurs, the lighter ones do not need to deal with it and can get better by themselves after resting. Most patients can relieve all the symptoms by inhaling oxygen or take certain drugs orally according to the doctor’s prescription. For acute plateau reaction headache can apply aspirin to relieve, can also apply some sedative drugs, such as diazepam, chronic plateau reaction can apply linezolid, medroxyprogesterone acetate, etc. to improve oxygen saturation.