Submucosal elevation of colon is not necessarily colon cancer, and it cannot be diagnosed as colon cancer just based on one symptom, but needs to be combined with comprehensive examination of the patient to confirm the diagnosis. Moreover, submucosal elevation of colon may also be other benign lesions, such as colon polyps, benign tumors of colon and so on. 1. Colon cancer: Its diagnosis should be made by doctor with the combination of patient’s medical history, family history, dietary habits, whether there are other intestinal diseases, patient’s clinical manifestations, X-ray, abdominal ultrasound, gas-barium double contrast, fecal occult blood test, tumor marker test, enteroscopy and pathology examination. 2. Colon polyps: polypoid lesions protruding from the mucosal surface into the intestinal cavity, with clinical manifestations of intermittent blood in stool or blood on the surface of the stool, usually bright red, patients may have a sense of urgency and then heaviness, and constipation or increased frequency of defecation can also occur. It should be noted that colon polyps have the possibility of malignant transformation. 3. Benign tumors of colon: including colon smooth muscle tumor and colon mesenchymal tumor, etc., invading the intrinsic muscle layer and submucosal layer, feasible endoscopic mucosal dissection, generally can be cured. If patients have submucosal elevation of colon, they should go to the hospital for relevant examination, and after clear diagnosis, doctors will formulate treatment measures according to the specific conditions of patients. If it is colon cancer, surgery should be performed as soon as possible. If it is other benign lesions, regular follow-up or surgery should be performed to prevent malignant changes. Meanwhile, the daily diet should be low in fat and high in fiber, as well as less pickled and fried foods.