Mr. Hu is 43 years old, is a garment foreign trade enterprise boss, the beginning of the business in order to fight for the cause, Mr. Hu and his wife can not care to have a child, pregnant twice went to the abortion. Now Mr. Hu manages a hundred or so people, career has been a small success, the idea of having children, but the last 2 years have not been pregnant, which has become a matter of concern. At first, he thought that his wife had had an abortion, but the results of the examination down but basically normal, so Mr. Hu went to the hospital to do a semen examination, the results were greatly unexpected: sperm activity rate of only 10%, 90% of the immobile sperm. Dr. Liu explained to him that the quality of semen used to be normal, but later it became poorer, and the common reasons are age, environment, lifestyle, infection and varicose veins. Age is an important factor affecting fertility. The best age for men is 25-35 years old, and the best age for women is 25-30 years old. Fertility declines significantly in women over 35 years of age, and in men, although not as pronounced as in women, fertility is also affected over 40 years of age. Last year a man in India at the age of 96 still made his 50-year-old wife give birth to a boy, and the famous domestic actor Wang Gang was also happy to have a son at the age of 60, but this is, after all, a relatively rare event. There have been numerous studies confirming that after the age of 40, the androgen level in men’s bodies decreases year by year, and that androgens are essential for sperm production and formation. Recently there was a 51-year-old man who wanted to have another child because of the unexpected death of his only child, and two 60-year-old men, one a professor and one a boss, both in very good health and having had children before, came to the hospital for examination because their wives were young and had fertility requirements after remarriage, and both were found to have very low sperm count or very low viability. Infection is also an important cause of reduced fertility. Mumps virus, gonococcus, and tuberculosis infection can all lead to reduced spermatogenesis or azoospermia. A man who had two children before later had bilateral epididymitis and came to the hospital some time ago and found no sperm in his semen. Varicocele is another common cause of male infertility, which affects semen quality due to poor blood return to the testicles. Some patients with varicocele have semen quality that is still in the normal range when they are young and does not affect fertility, but as they grow older and the varicocele lengthens, semen quality will gradually decline, thus affecting fertility. In addition, the fast pace of life, work pressure, high-temperature work, environmental pollution, radiation, smoking and alcohol, hot springs, sauna, driving sedentary, obesity, etc. are the “culprits” that lead to the decline of semen quality year by year. Therefore, Dr. Liu suggests that men should have children before it’s too late, while avoiding bad lifestyles, and once semen quality declines, actively look for the cause and treat or treat the cause. There are also a significant number of people who cannot find a clear cause and can be treated with empirical medication for 3 to 6 months, and some people can still improve. For patients whose semen quality cannot be improved, they can also be treated with assisted reproduction techniques, such as artificial insemination, in vitro fertilization-embryo transfer (IVF) technology, which in theory can achieve the desire to be a father as long as there is an active sperm.