Erythema of the skin after taking Helicobacter pylori medication is usually considered as a side effect of epidermal sensitization caused by the drug ingredients. Timely treatment can be relieved. At present, the drugs usually used for the treatment of H. pylori are mainly omeprazole, clarithromycin and so on. Meanwhile, the standardized anti-Helicobacter pylori quadruple therapy includes two antibiotics, proton pump inhibitors and bismuth. The antibiotics and proton pump inhibitors may cause different degrees of epidermal allergy, itching or erythema during use, which are common adverse drug reactions. When Helicobacter pylori patients in the process of taking medication due to the drug components caused by epidermal abnormalities, can be timely under the guidance of the doctor to choose to adjust the type of antibiotics or change the treatment program, through the reasonable avoidance of allergic drug components to effectively alleviate the phenomenon of epidermal abnormalities. Generally, the epidermis will gradually return to normal in about a week after changing drugs or stopping drugs. After taking the H. pylori medication, if the common side effects of the medication occur, you should consult your doctor’s advice in time to choose the appropriate solution.