Methylprednisolone can not be stopped immediately after one week. Methylprednisolone belongs to the adrenal glucocorticoid hormone, generally need to according to the patient’s own situation gradually reduce the drug, until there is no withdrawal syndrome and relapse of the disease, can completely stop the drug. Methylprednisolone is an adrenal glucocorticoid with anti-inflammatory, analgesic and antipyretic effects. Methylprednisolone is commonly used in rheumatic immune system diseases such as rheumatoid arthritis, allergic diseases such as bronchial asthma, inflammatory diseases such as gouty arthritis, skin diseases such as pemphigus, etc. It can also be used in the prevention of rejection after organ transplantation and emergency treatment of critical diseases. Discontinuation of Methylprednisolone immediately after use may cause withdrawal syndrome, leading to recurrence of the disease, therefore, immediate discontinuation of the drug is not recommended. Therefore, it is not recommended to stop the drug immediately. Usually, it is necessary to gradually reduce the drug according to the patient’s own situation, until there is no withdrawal syndrome and recurrence of the disease, and then completely stop the drug. Methylprednisolone can cause infections, elevated blood glucose and blood pressure, dizziness and headache, arrhythmia, nausea, vomiting and other adverse reactions. It is forbidden to use it in people who are allergic to the product, people with systemic fungal infections, and it is used with caution in people with epilepsy, hepatic and renal insufficiency, and patients with myasthenia gravis. Methylprednisolone can not be stopped immediately after taking a week, it is recommended to take and reduce the dosage under the guidance of a doctor until the drug is discontinued, do not stop taking the drug on your own, so as to avoid adverse consequences.