Progesterone can not be taken for a long time, because progesterone is a hormone drug, used for low progesterone in the first 3 months of pregnancy or after IVF, also used to regulate menstruation and fetus treatment, different conditions, the dose and duration of treatment is different, long-term use of progesterone will cause fat, nausea, vomiting, breast pain and other side effects. Progesterone can also damage the liver over a long period of time. It is important to check the liver function during the medication period, and if the transaminases rise significantly, you should stop the medication in time and take liver-protective drugs to improve it. During the application of progesterone, the correct use of drugs must be under the guidance of a doctor, do not blindly use drugs. It is recommended to pay attention to the diet during the oral medication, mainly a light diet, avoid eating too greasy food, eat more fresh vegetables and fruits, ensure sufficient sleep, and appropriate activities.