Swelling and pain in the palm of the hand may be caused by local infection, palm trauma or gouty arthritis. 1. Local infection: if the palm of the hand by foreign objects stabbed, scratched, did not get timely disinfection treatment, it may lead to the palm of the soft tissue of the septic infection, usually manifested in the palm of the local swelling, pain and other discomfort. 2. Palm trauma: if the life caused by local soft tissue contusion and other hand trauma, will also be manifested as localized swelling, pain and activity limitation, and in serious cases, there may be hand tendon injury or even metacarpal bone fracture. 3. Gouty arthritis: the cause of gouty arthritis considerations may be related to abnormal purine metabolism in the body, hyperuricemia, genetic factors, etc., the concentration of uric acid in the blood is too high, resulting in monosodium urate crystals deposited in the joints around the cause of inflammatory reaction, it will trigger gouty arthritis, involved in the hands, there will also be swollen palms, pain. Due to the cause of swelling and pain in the palms of the hands of more reasons, there may also be cervical spondylosis and arterial embolism and other diseases, if the discomfort persists or signs of aggravation, it is recommended to go to the hospital in a timely manner for examination and diagnosis, and to clarify the cause of the disease as soon as possible to take targeted therapeutic measures, so as to avoid delaying the condition.