Insulin is the only hormone secreted by the pancreatic β-cells of the human body that can lower blood glucose, and its secretion can be increased by oral medications, such as glibenclamide and reglaneride, etc., and it is generally not possible to increase its secretion by consuming special foods.
Insulin is synthesized and secreted by pancreatic β-cells and reaches the target cells in various tissues and organs in the body through blood circulation. Current medications act mainly on pancreatic β-cells. Stimulate increased secretion of insulin.
Sulfonylurea hypoglycemic drugs exert hypoglycemic effects by binding to the sulfonylurea receptor on the pancreatic islet β-cell membrane, shutting down the β-cell potassium pump channel, leading to depolarization of the β-cells, facilitating an increase in the inward flow of calcium ions, and promoting the release of insulin, whose hypoglycemic effect depends on the survival of a considerable number of functional pancreatic islet β-cell tissues. Common drugs include glibenclamide, glipizide, glimepiride and so on.
Glargine-type hypoglycemic drugs are non-sulfonamide pro-insulin secretagogues, which act on ATP-sensitive potassium channels in the pancreatic islet β-cell membrane, but with slightly different binding sites. Common drugs include Repaglinide and Naglinide.
Insufficient insulin secretion, oral medication can be taken to promote insulin secretion, the use of the above drugs have certain risks, it is recommended to seek medical attention in a timely manner, the drugs need to be used under the guidance of a professional doctor.