Whether a targeted drug is effective against bone metastasis depends on whether there are changes in the driver genes in the patient’s body. If there is a change of the driver gene in the body, such as gene mutation, or amplification, expression, or changes in the form of fusion, and it is found that there is a clear relationship with the occurrence of the tumor; at this time, for the patients with positive driver gene, the effect of targeted therapy is more effective, and the effective rate can reach 70%~80%, but it needs to be analyzed and judged according to the specific analysis and judgment. However, there are also patients whose pathology is not sensitive to targeted drugs, and if the local blood circulation of bone metastases is relatively poor, the drug may penetrate into the local concentration is low. If the targeted drug is ineffective, local treatment, such as surgical treatment and local radiotherapy, needs to be carried out for the site of bone metastasis in order to effectively control the bone metastasis. It is recommended that the patient should consult the doctor in time, communicate with the attending physician about the treatment plan, and follow the doctor’s instructions to standardize the treatment.