Whether a high monocyte count is important depends on the cause of the elevation. Elevated monocyte counts are categorized into physiological and pathological elevations; physiological elevations are mostly transient and can return on their own after a period of time. Pathological factors include infectious diseases, hematologic diseases, rheumatic immune system diseases, etc. Monocytes can return to normal after correcting the primary disease. 1. physiologic monocyte elevation: most common in infants and young children, it is a normal phenomenon; sometimes adults may also have high monocyte in a single test, if there is no other abnormal result or symptom, it can be followed up and observed. 2. Pathologic monocyte elevation: (1) Infectious diseases: cytomegalovirus infection, EBV infection, malaria, syphilis, etc., most of them are combined with fever, rash, diarrhea and other manifestations, and the pathogenic examination can make a clear diagnosis. It is recommended to give anti-infection treatment and symptomatic treatment under the guidance of doctors. (2) Hematological diseases: mononuclear cell leukemia, etc., may be combined with bleeding, anemia, emaciation, fever and other manifestations, improve the bone penetration and other tests to clarify the diagnosis, the treatment is mainly based on chemotherapy, and hematopoietic stem cell transplantation is feasible under the condition. (3) Rheumatic immune diseases: systemic lupus erythematosus, etc., may have fever, erythema, skin rash, etc., may have multi-system involvement, autoantibodies may be positive, treatment is based on glucocorticoids and immunosuppressants. Risk warning: Higher monocytes may indicate a certain significance of the disease, it is recommended to go to the hospital for a clear diagnosis.