Calcification of duodenal bulbous nodes does not usually cause pancreatic duct dilatation. The common causes of pancreatic duct dilatation are mainly physiologic and pathologic causes. Physiologic causes are that the pancreatic duct will gradually dilate due to aging. Pathological causes are mainly pancreatitis, pancreatic tumors, pancreatic duct stones, tumors of the lower end of the common bile duct, and duodenal papillary tumors. The pancreatic duct and common bile duct open together in the duodenal greater papilla, which is located in the descending part of the duodenum, while the duodenal bulb is at the beginning of the duodenum, so nodular calcification in the duodenal bulb does not usually cause pancreatic duct dilatation. When pancreatic duct dilatation is detected, the cause needs to be actively searched for, and the cause needs to be addressed and treated promptly.