Amikacin sulfate is a semi-synthetic aminoglycoside antibiotic, it is the same class of drugs as gentamicin and streptomycin, and its mechanism of action is to inhibit bacterial protein synthesis. It is mainly used clinically for infections caused by Gram-negative bacilli, and Staphylococcus aureus which are resistant to penicillinase. It is mainly used for respiratory tract infections, central nervous system infections, abdominal cavity infections, biliary tract infections, bone, joint and skin soft tissue infections, burns, post-surgical infections, urinary system infections, and other serious infections such as bacterial endocarditis, sepsis, etc. caused by sensitive bacteria. Amikacin is also used as a second-line drug for anti-tuberculosis treatment, and its main adverse effects are ototoxicity and nephrotoxicity.