Indapamide can lower blood pressure in 24 hours after taking the drug, and the maximum antihypertensive effect can be achieved in 8~12 weeks. Indapamide is a diuretic, belongs to the strong, long-acting antihypertensive drugs, can block sodium inward flow, relaxation of vascular smooth muscle, so that the peripheral vascular resistance decreased, to achieve the effect of lowering blood pressure. Oral absorption is fast, oral 24 hours can achieve antihypertensive effect, continuous administration for 8~12 weeks can achieve the maximum antihypertensive effect. Severe renal insufficiency, severe hepatic insufficiency, patients allergic to indapamide or sulfonamides should be prohibited. Use with caution in patients with hypokalemia and those with gout. Indapamide can cause hypokalemia, pay attention to more testing of serum potassium during the use of the drug. Hypertensive patients if the continuous 8~12 weeks of blood pressure control is not up to standard, to the hospital timely consultation, adjustment of antihypertensive drugs, can consider the combination of drugs to lower blood pressure.