Platelet 1000 refers to the number of platelets in the peripheral blood is 1000×10^9/L, platelet count is significantly increased. The cause of the disease needs to be clarified in a positive and timely manner, during which the patient needs to keep drinking plenty of water and eating a light diet; antiplatelet drugs such as aspirin can be taken orally to prevent thrombotic disease. If it is caused by infection, anti-infection treatment should be carried out until the platelets can be decreased. If the platelet elevation is caused by splenectomy, generally there is no need for platelet-lowering treatment, and oral aspirin can be used to prevent thrombosis by anti-platelet aggregation. If the patient has trauma, craniotomy and other obvious triggers, it is necessary to control the primary disease and antiplatelet therapy until the number of platelets return to normal. If the platelet reaches 1000×10^9/L for unknown reasons, it may be primary thrombocythemia, and bone marrow aspiration is needed to confirm the diagnosis, and the diagnosis can be treated with hydroxyurea or interferon to lower the cells. The normal reference range for platelets is 100-300×10^9/L. It is recommended to consult a medical professional for advice. Medications should be used under medical supervision.