Since the progestin component of Estramin affects lipid metabolism in women, it is best not to take it if the blood lipids are usually high and patients with atherosclerosis. In addition, because estrogenic drugs can increase the activity of renin and raise blood pressure, patients with hypertension should not take them either. Estrogen can also cause hypercoagulability in the body, so patients with blood disorders and thrombotic diseases, as well as patients with familial myocardial infarction and cerebral hemorrhage should not take it. In addition, patients with endocrine diseases, such as diabetes or hyperthyroidism, are advised not to eat it. Patients with malignant tumors or lumps in the uterus or breast should also not take it because the estrogen content in Eusebio can cause the lumps to increase in size. In addition, women older than 45 years old should not take it because they are approaching menopause.