Adenosine deaminase is mainly used as a sensitive indicator to assess liver injury and can be used as one of the items in routine liver function tests. When there is high adenosine deaminase, it is necessary to consider the possibility of various diseases, such as autoimmune diseases, liver diseases, tuberculosis, hematological system diseases, etc. It is recommended to go to hospital to improve the examination and make a clear diagnosis for treatment. 1. Autoimmune diseases: The common cause is mainly systemic lupus erythematosus, which can cause the accumulation of fluid in the chest or joint cavity, and by testing the blood and fluid, there may be high adenosine deaminase The result is that the degree of increase is related to the severity of the disease. It may be accompanied by clinical manifestations such as joint and muscle pain, malaise and fever, and usually requires the application of glucocorticoids or immunosuppressive therapy, such as prednisone and cyclophosphamide. 2. Liver disease: It can lead to acute liver injury, which in turn causes high adenosine deaminase, such as chronic hepatitis and cirrhosis, and patients with hepatocellular carcinoma can also have high adenosine deaminase. Clinically, it can be accompanied by weakness, loss of appetite, and even liver palm, spider nevus, etc. If it is caused by liver injury, it is necessary to actively carry out liver preservation treatment, such as oral magnesium isoglycyrrhizate; 3, tuberculosis: because when suffering from tuberculosis, the results of high adenosine deaminase can appear in the patient’s serum, chest and abdominal fluid, cerebrospinal fluid and bronchoalveolar lavage fluid, and the elevated value of adenosine deaminase can be used to identify tuberculous and cancerous pleuritis. It is often accompanied by cough, hemoptysis, hypothermia, body wasting and other manifestations, requiring anti-tuberculosis treatment, commonly used drugs such as isoniazid, rifampin, etc.; 4. Hematologic diseases: Hematologic diseases can lead to high adenosine deaminase, which can be used for clinical staging and typing diagnosis of leukemia, the specific mechanism of elevation is not clear, often accompanied by anemia, fever and other manifestations clinically. For hematologic disorders, it is recommended to visit a hematology specialist for treatment, applying nutritional support, stem cell therapy, etc.