Meige’s syndrome (Meige’s syndrome) is a segmental dystonic disorder. It was first reported by French neurologist Meige in 1910. It is mainly characterized by bilateral blepharospasm and involuntary facial dystonia-like movements, also known as blepharospasm with mandibular dystonia. In severe cases, it can cause severe symptoms such as difficulty in eye opening, functional blindness, difficulty in swallowing, difficulty in whistling, and dysarthria, causing extreme pain to patients. For Major’s syndrome, because its clinical manifestations are similar to many diseases, it can be easily confused with dry eye, facial spasm, myasthenia gravis, senile ptosis, tic disorder, and post-facial paralysis linked movement. Meijer syndrome is a relatively rare disease in clinical practice, with an incidence of about 1/20,000. Therefore, in the early stage, due to the lack of understanding of the pathogenesis of the disease and the limitation of the treatment methods, the treatment methods for the disease were particularly confusing, and most patients were misdiagnosed as facial muscle spasm and used apparent microvascular decompression, which is not caused by the compression of the facial nerve root by blood vessels because the pathogenesis of the disease, so the use of this method The treatment is ineffective. There are also surgical procedures such as facial nerve avulsion, orbicularis oculi avulsion or excision, facial nerve orbicularis oculi branch destruction, facial nerve combing and stereotactic brain deep nucleus destruction, etc. These surgical procedures are mainly destructive and may lead to permanent facial paralysis, muscle atrophy, keratitis, etc. Long-term corneal exposure in some patients may lead to corneal ulceration, perforation and even blindness. Serious complications, due to the poor efficacy and high incidence of complications of these surgical procedures, are rarely used in clinical practice today. At present, the internationally recognized method for the surgical treatment of Meijer syndrome is Deep Brain Stimulation (DBS), commonly known as “brain pacemaker” surgery, which is less invasive, faster recovery, non-destructive to the normal brain structure, reversible, adjustable, personalized, etc. It is a safe and effective method with fewer side effects. It is a safe and effective treatment with fewer side effects. The disadvantage is that it is more expensive at present. The Neurology Center of the General Aviation Hospital is one of the first few centers in China to carry out this type of surgery, and the number of cases and efficacy of the surgery are in the leading position both at home and abroad, with an efficiency rate of over 80-90% and an improvement rate of 77-90% on average, and more than half of the patients have completely disappeared and returned to normal life after surgery. syndrome is a useful option for patients with drug-refractory Meige syndrome, which can significantly improve the symptoms and improve the quality of life. However, the treatment of Meige syndrome is still basically in symptomatic treatment, and there is still a lack of specific methods for its eradication at home and abroad, and further research is needed.