Orange-red mucosa on the esophagus may suggest esophagogastric mucosal ectasia or esophageal reflux, which can be recovered after active treatment and is not scary. When the patient occurs esophagogastric mucosal ectasia, it may lead to the appearance of orange-red mucosa on the esophagus, which is due to the appearance of gastric mucosal tissues on the esophagus, which will secrete gastric acid, and the gastric acid stimulates the esophageal mucosa, which may lead to inflammation of the esophagus, and the mucosa will become orange-red in color. After standardized treatment under the guidance of professional physicians, the condition can be effectively relieved and the prognosis is better. Esophageal reflux is a common cause of inflammation of the esophageal mucosa. The relaxation of the cardia can lead to the reflux of gastric acid into the esophagus, which stimulates the esophageal mucosa and causes inflammation, resulting in a reddish-orange color of the mucosa. After active treatment, the patient may recover, but if left untreated, Barrett’s esophagus may develop, and even esophageal cancer may occur. When the above situation occurs, it is recommended to go to the hospital in time. Timely intervention in the early stage of the disease usually has a better prognosis, so as to avoid delaying the treatment time, which may lead to serious consequences.