A hepatic encephalopathy coma is usually still possible to wake up, but in a few patients with severe disease, they may never wake up. If a patient with hepatic encephalopathy goes into a coma, it is usually caused by severe liver disease, such as advanced cirrhosis. If detected early, after timely and effective treatment, the condition is under control and most patients can wake up. However, some patients with more severe hepatic encephalopathy, such as cerebral edema and intracranial hypertension, may not be able to wake up, and may even endanger their lives. Once the hepatic encephalopathy coma occurs, it is recommended to go to the Department of Hepatology of regular hospitals as soon as possible, and be resuscitated by professional doctors urgently, so as to avoid the patient’s condition from becoming more serious. During the later treatment period, the patient must cooperate with the doctor to improve the relevant examinations, actively formulate reasonable treatment measures, and at the same time, prevent the emergence of various complications such as lung infections, urinary tract infections, and bedsores, so as to avoid leaving hidden health risks.