In general, aspirin can be replaced by clopidogrel or tigretol, which selectively inhibit the binding of adenosine diesterase and platelet receptors, thereby inhibiting platelet aggregation. Therefore, they can replace aspirin in the prevention or treatment of acute ischemic stroke, myocardial infarction, or peripheral arterial vascular occlusion due to platelet aggregation. Patients in whom aspirin is not effective can be replaced with clopidogrel or tigretol, but after acute coronary syndrome or stenting, a combination of aspirin and another antiplatelet agent is required for 1 year to prevent thrombotic events.