Callus pain is generally caused by the thickened corneal plaque above the plane of long-term friction or in the case of trauma, resulting in bacterial invasion and infection. For those with mild pain, soak in warm water and then use a knife to flatten the callus to avoid long-term pressure and friction, and it is recommended to wear soft-soled and loose shoes to reduce the number of walks to reduce pain. At the same time, callus pain should also be anti-inflammatory and antibacterial treatment, such as oral administration of a Qing capsule, Shuanghuanglian oral liquid, and with penicillin V potassium tablets or amoxicillin capsules, with heat, detoxification, cooling effect, but also to achieve the effect of anti-inflammatory. In addition, you can also apply local wet application of skin health lotion or compound cypress liquid application, which can play the role of cooling blood, detoxifying and lowering fire. After wet application, you can apply fusidic acid cream, compound polymyxin B ointment, vitamin A acid cream or compound flumethasone ointment to strengthen the anti-inflammatory effect. If the pain is difficult to be relieved, patients are advised to go to a local general hospital or specialist hospital to see a doctor in the relevant department for consultation. In addition, those who have the conditions can also undergo medical aesthetic treatment, using fruit acid or salicylic acid for peeling, photorejuvenation treatment, or using liquid nitrogen freezing treatment, which can largely relieve the pain symptoms.