Few parents ask, “The HFMD vaccine is only on the market, is it safe?” “Will there be adverse reactions to HFMD vaccination?” “Will I not get HFMD after vaccination?” Don’t worry, what you want to know, medical experts tell you! April to June is the high incidence of hand, foot and mouth disease every year, and it even lasts until October. Individual children may have recurrent infections, causing much distress to parents. The EV71 vaccine for HFMD, the “nemesis” of HFMD, has been officially launched. First, what is hand, foot and mouth disease? Hand, foot and mouth disease is an infectious disease caused by a variety of enteroviruses, EV71 is one of the important pathogens leading to hand, foot and mouth disease, mostly in infants and young children. There is a lack of specific therapeutic drugs for this disease. Therefore, EV71 vaccination can effectively prevent and control the epidemic of HFMD in children caused by EV71 virus, especially reduce the occurrence of severe cases and deaths. Clinical research data show that the protection rate of the vaccine against HFMD caused by EV71 virus infection is 97.3%. Second, the safety of the vaccine? Clinical research data show that the local reaction after vaccination is redness, hardness, pain, swelling, itching, etc., which is mainly mild and lasts no more than 3 days, and can be relieved by itself. Systemic reactions mainly manifested as transient fever, diarrhea, loss of appetite, nausea, vomiting, irritability and so on. The incidence of all symptoms with a severity of grade 3 or higher, such as fever, diarrhea, nausea and vomiting, did not differ significantly between the vaccination group and the control group. The results show that EV71 vaccine has good safety. Third, the use of EV71 vaccine recommendations 1, the vaccination population: the age of vaccination for 6 months – 5 years. In the Technical Guidelines for the Use of Inactivated Enterovirus 71 Vaccine, China CDC recommends that the vaccine should be administered to susceptible children ≥6 months of age, and the earlier the vaccination, the better. Completion of the vaccination program before 12 months of age is encouraged so that the protective effect can be realized as early as possible. For children over 5 years old, vaccination is not recommended. Vaccination procedure: 2 doses of basic immunization, with an interval of 1 month; the need for booster immunization has not yet been determined. 3.Vaccination route and dose: intramuscular injection into the deltoid muscle of the upper arm. The dose of each vaccination is 0.5ml. 4, contraindications for vaccination: known allergy to any of the components of the EV71 HFMD vaccine, fever, patients with acute illness and patients with acute exacerbation of chronic diseases should not be vaccinated. Precautions: 1, if the child has had hand, foot and mouth disease before, and is not caused by EV71 virus, can still be vaccinated with EV71 vaccine. 2, EV71 vaccination and injection of human immunoglobulin should be separated by at least 1 month. 3. It is recommended that the interval between EV71 vaccine and other vaccination should be more than 2 weeks. 4. It is recommended to use the same company’s vaccine to complete two doses of vaccination. HFMD EV71 vaccine is effective against HFMD caused by EV71 infection, but not against HFMD caused by other types of enterovirus infection. Parents should pay attention to urging their children to develop good personal hygiene habits, wash their hands frequently, exercise more often, strengthen their physical fitness, and visit less crowded public places to reduce the chance of being infected. The following conditions should be carefully considered when deciding whether or not to vaccinate: 1. People with thrombocytopenia or bleeding disorders. 2. Patients who are receiving immunosuppressive therapy or immunodeficiency. 3, Patients with uncontrolled epilepsy, other progressive neurological diseases such as Guillain-Barre syndrome.