Many people have asked whether children with congenital heart disease can be vaccinated. Some doctors at primary vaccination stations also have doubts about this. First of all, congenital heart disease and vaccination are not necessarily and directly related. Vaccination is the application of attenuated or inactivated vaccines to children to create immunity to disease. The process of producing immunity is essentially an allergic reaction. An unexpected event during vaccination is also an excessive allergic reaction. Severe and excessive allergic reactions can result in a state of shock. In fact, the possibility of allergy exists in any infant, and it can occur in any healthy and sick infant. Therefore, the prevention of excessive allergic reactions is the key in vaccination efforts. It is the physician’s job to prepare a plan for prevention and prevention of hypersensitivity, not to deny vaccination to a child because he or she has congenital heart disease. Preventive measures include taking a careful medical history, such as whether the child is allergic to anything, family history, and whether there has been any recent fever, cough, diarrhea, colds, pneumonia, heart failure and other infectious diseases. Vaccination should be postponed for those with recent occurrences until they have recovered. Delayed development, such as those with significantly lower weight and height than children of the same age, can also be postponed. In case of anaphylactic shock, immediate targeted resuscitation treatment should be provided. For example, epinephrine, hormones, oxygen, etc.