You can take metronidazole, amoxicillin or nux vomica pills for toothache and fire. Toothache on fire is mainly due to tooth pain caused by a decrease in resistance. In this case, the tooth itself may be decayed or the bacteria may have infected the tooth nerve. Bacterial invasion ability and the body’s own resistance are in a dynamic balance, fire causes the body’s immunity is low, resistance decreases, pain will occur. If the tooth itself exists decay, it can be treated with oral metronidazole or amoxicillin. Metronidazole is mainly for oral anaerobic bacteria or Staphylococcus aureus infection, most of the bacteria in the root canal of teeth are anaerobic bacteria, and metronidazole has a very good effect of anti anaerobic bacteria. Alternatively, oral amoxicillin may be used for treatment. Toothache on fire may also be a manifestation of fire, eating too much hot stuff in the body, you can take Niuhuang detoxification pills orally to lower the fire. If the pain is unbearable or affects your normal life, you can also take ibuprofen orally for pain relief, and if you have tooth decay, you need to have dental treatment as soon as possible. Therefore, you can take metronidazole and cephalosporin for anti-inflammatory, or niuhuang detoxification pills to lower the fire, and also oral ibuprofen for acute pain relief.