Patients with chronic atrophic gastritis can’t take omeprazole for a long time. Chronic atrophic gastritis refers to the gastric mucosal cells being damaged and stimulated by various factors, resulting in the atrophy of the gastric mucosal glands, which loses the function of secreting gastric acid and pepsin. Gastric acid and pepsin, as the main digestive fluid for digestion and food decomposition, will weaken the function of food decomposition and digestion once the secretion is reduced. Because patients with atrophic gastritis itself gastric mucosa cell atrophy, gastric mucosa cell atrophy after gastric acid secretion is less than normal, and omeprazole is an acid-suppressing drug, omeprazole itself can lead to a decrease in gastric acid, so patients with atrophic gastritis if you take omeprazole for a long period of time, will make the original already less gastric acid become even less, and will also lead to a lot of complications, for example, patients with atrophic gastritis long-term Eating omeprazole will aggravate the symptoms of atrophic gastritis, leading to the patient digestion, absorption function is weakened, and long-term intake may also cause an increase in the chances of gastric cancer, but also lead to osteoporosis, the drug rebound and other adverse reactions, so atrophic gastritis patients can not eat omeprazole for a long time.