Amyloid dermatitis here refers to primary cutaneous amyloidosis, which is mainly divided into mossy cutaneous amyloidosis and patchy amyloidosis. Primary cutaneous amyloidosis currently has no effective treatment, mainly symptomatic treatment, such as drug therapy, physical therapy and so on. 1. Drug treatment: if the skin has obvious itchiness, antihistamines can be given, such as loratadine and cetirizine, which can relieve the itchiness. Topical strong glucocorticoid preparations, such as halometasone, fluticasone propionate ointment treatment. 2. Physical therapy: mainly includes ultraviolet radiation therapy, liquid nitrogen cold rubbing therapy, laser therapy and other methods. To summarize, there is no satisfactory treatment for primary skin amyloidosis. It is recommended to combine with the doctor’s advice on symptomatic treatment, which can improve the quality of life of patients. Drugs need to be used in accordance with medical advice.