There are many reasons for gallbladder wall thickening of 1.1cm, such as acute cholecystitis, gallbladder stones, cirrhosis, etc. Its severity needs to be assessed comprehensively according to clinical symptoms. 1. Acute cholecystitis: mostly caused by bacterial infection, in addition to various causes of increased pressure in the gallbladder cavity can also be caused. Acute cholecystitis will present with abdominal pain, fever and other manifestations, and there may be obvious thickening of the gallbladder. It can be cured after active treatment and usually has no serious consequences. 2. Gallbladder stones: Long-term gallbladder stones can lead to thickening of the gallbladder wall, even to chronic cholecystitis, which may lead to cancer if left untreated. 3. Cirrhosis: due to the abnormal liver function, the venous return of gallbladder is blocked, which leads to the swelling of gallbladder wall. This situation suggests that liver cirrhosis enters into the stage of decompensation, which is more serious and the primary disease should be treated as early as possible. Therefore, the presence of gallbladder wall thickening of 1.1cm should be promptly consulted and treated under the guidance of a doctor.