Nerve block therapy is an important tool in the treatment of chronic pain, and it is less damaging, more effective and better tolerated than surgical treatment. In clinical work, patients often ask whether nerve block therapy is “closed”, and many patients lose the best time for nerve block therapy because of the fear of “closed”. At present, some doctors who are not specialized in pain management, and even some nursing staff, due to the lack of systematic knowledge and training, are keen to inject multiple drugs at pain points, so-called acupuncture points or nerve endings to relieve pain, and they call themselves “closed therapy”, which means closed pain. There are even some social loafers, in order to cheat money for the purpose of “a needle away”, “closed” everywhere, so that the word “closed” added a serious bad color. Before the establishment of the pain profession, the word “closed” was widely spread, so that some medical personnel and some patients also have a misunderstanding of the formal nerve block, and even fear. The difference between nerve block therapy and “closed treatment” is as follows: the use of different drugs “closed” generally uses a high concentration of local anesthetic drugs for analgesia, while the nerve block compound generally uses only a lower concentration of local anesthetic drugs to achieve the therapeutic effect of anti-inflammatory pain relief Therefore, limb dysfunction is less likely to occur. The location of “closed” injection is at the site where the patient complains of pain, while nerve block is to inject drugs into the primary lesion according to the law of nerve travel and innervation, such as stellate ganglion block, the treatment site is in the neck, but can treat neurasthenia, insomnia, sympathetic cervical spondylosis, complex regional pain syndrome and other difficult cases. The technical operation requirements are different. “Closure” only injects the drug into the painful local area, mainly “that pain hit that”, the accuracy requirement is not high, while the nerve block is a technical operation that must undergo a long period of professional training before it can be implemented correctly. In order to achieve the desired goal of treatment, the nerve block must be diagnosed, the innervated nerve causing the pain must be identified, and the drug must be injected accurately into the diseased nerve. Because of the high technical requirements of nerve block therapy, only experienced doctors are required to perform it. The diagnosis of the cause of pain is different. The effect of “closure” is only to temporarily block the transmission of pain signals. In contrast, the diagnosis must be clear before the nerve block is performed, and the primary lesion must be known, and the drug must be injected into the primary lesion. Like saving a withered tree, whether the root cause is insect damage in the tops, bark damage in the trunk, or decay in the roots, the treatment must be clear and targeted before administering. The characteristic of nerve block treatment is “to deliver the most needed drugs in the most direct way, exactly where they are needed”. Different judgment on the cause of pain “Closure” is based on the area where the patient complains of pain, and there is no way to determine the cause of nerve conduction pain and the primary lesion. In contrast, nerve block therapy is a treatment that seeks the cause and targets the primary lesion, and has a diagnostic effect on the cause of pain. In conclusion, nerve block therapy plays a unique role in clinical pain management and occupies an important role, with few complications and no so-called addiction as long as it is performed properly. The new concept of “pain point” injection is not exactly the same as the so-called “closure”, and it can often be effective in the treatment of acute attacks of chronic pain or new muscle and soft tissue pain, so there is no need to have unnecessary fear.