Diclofenac sodium and ibuprofen both belong to the non-steroidal anti-inflammatory drugs, both have certain side effects, there is no which drug has less side effects. And due to different factors such as personal constitution and medication, the size of the adverse reaction of the patient also has some differences. Therefore, it is impossible to compare diclofenac sodium and ibuprofen, who has fewer side effects. 1. Diclofenac sodium: has analgesic, anti-inflammatory, antipyretic effect. It is suitable for non-articular soft tissue rheumatic pain, acute mild and moderate pain and other diseases. This product may cause adverse reactions such as dyspepsia, nausea, itching, nasal congestion, increased blood pressure, swelling and pain in the arms or legs. It is contraindicated for those who are allergic to the product, suffering from liver or kidney failure, severe heart failure and other diseases. Avoid combining with other non-steroidal anti-inflammatory drugs, including selective COX-2 inhibitors. 2. Ibuprofen: It has antipyretic, analgesic and anti-inflammatory effects. Commonly used in the treatment of arthritis, primary dysmenorrhea and other diseases. Ibuprofen can cause skin rash, hypernatremia and other common adverse reactions, and erythroderma and other serious adverse reactions. It is contraindicated for those who have undergone coronary artery bypass grafting and those who are allergic to the product. Note that this product is a symptomatic drug, used for analgesia should not exceed 5 days, used for antipyretic should not exceed 3 days. Both can cause certain adverse reactions, due to individual and medication differences, so there is no diclofenac sodium and ibuprofen which side effects are smaller. It is recommended to take diclofenac sodium or ibuprofen as prescribed by the doctor, do not take it without authorization, so as not to cause adverse consequences.