FSGS’s are focal segmental glomerulosclerosis, and its treatment outcome cannot be generalized and is influenced by factors such as pathological subtype, clinical symptoms, and treatment sensitivity. FSGS manifests as lesions in some (focal) glomeruli and/or some capillary collaterals (segments) of the glomeruli. Lesions first involve the deep paramedullary glomeruli of the renal cortex; significant tubulo-interstitial lesions can be seen at an early stage. Proteinuria and nephrotic syndrome are prominent clinical manifestations. Among the pathologic factors affecting patient outcome, renal interstitial fibrosis is the primary factor. Focal segmental glomerulosclerosis apical type has a high rate of remission on treatment and has a better prognosis, while the collapsed type is the most difficult to remit and has the worst prognosis, and the prognosis of other types of FSGS is not uniform. People with milder clinical signs and degree of proteinuria in FSGS are better treated than those with heavy clinical signs and proteinuria. Focal segmental glomerulosclerosis that is more sensitive to treatment has a better outcome than those that are not. Therefore, when the diagnosis of focal segmental glomerulosclerosis is confirmed, one should go to the hospital in time and have regular treatment under the guidance of professional physicians.