It is not too recommended to mix imported and domestic hepatitis B vaccines. As long as the required 3 injections are completed, i.e. 0, 1 and 6 months, the corresponding hepatitis B surface antibodies can be produced and last for about the same period of time. However, mixing imported and domestic hepatitis B vaccines does not comply with the corresponding injection process. It is better to use the hepatitis B vaccine produced by the same manufacturer, and if two manufacturers, or domestic and imported, or different sizes of hepatitis B vaccines are used for injection, the amount of antibodies will be affected to some extent, although not to a particularly large extent. And some hepatitis B vaccines use different specifications, from 10 μg to 20 μg. If the imported and domestic specifications are different, the effect will be different.