| Grading |
Clinical presentation |
Treatment recommendations |
Grade 1
| Single largest diameter ≤10mm with or without ruptured bleeding |
Continue medication and use gauze to protect friction-prone areas from bleeding. Those with ruptured bleeding may be treated with local compression to stop bleeding |
| Grade 2 |
Single maximum diameter >10 mm with or without ruptured bleeding |
Continue medication and use gauze to protect friction-prone areas from bleeding. For ruptured bleeding, local pressure may be applied to stop bleeding, or local therapeutic measures such as laser or surgical excision may be taken. Avoid infection at the site of rupture |
| Grade 3 |
Pancreasized, can be complicated by skin infection, may require hospitalization |
Suspend medication and resume administration after recovery to grade ≤1. The friction-prone area may be protected with gauze to avoid bleeding. Local pressure may be applied to stop bleeding in cases of rupture and bleeding, or local therapeutic measures such as laser or surgical excision may be taken, and anti-infective treatment is given in cases of co-infection |
| Grade 4 |
Multiple and pancytopenia, life-threatening |
Permanent discontinuation of medication |
| Grade 5 |
Death |
|