Typical symptoms of multiple myeloma stage I include bone pain, anemia, renal function impairment, bleeding and other symptoms. 1. Bone pain, most common in lumbosacral region, followed by chest and lower limbs, and those with severe pain after activity or sprain may have pathological fracture, mainly due to the imbalance of osteoclast and osteoblast activities. 2. Anemia, manifested as pale skin, blepharoconjunctiva, white lips, fatigue, dizziness, etc., which is caused by the decrease of erythropoiesis due to the suppression of myeloma, and the hemoglobin is lower than normal value. 3. Renal function impairment, manifested as proteinuria, hematuria, tubular urine, elevated uric acid and other symptoms. It is mostly due to the deposition of weekly protein in the epithelial cells of renal tubules, which causes damage to their cellular function. 4. Bleeding, with bleeding from skin, gums and nasal cavity being the most common, the bleeding mechanism is related to thrombocytopenia, impaired platelet function and coagulation dysfunction. Multiple myeloma is a malignant proliferative disease of plasma cells, which is characterized by abnormal proliferation of clonal plasma cells in bone marrow, leading to damage of related organs or tissues. There are many other symptoms, and if you have unexplained symptoms, you need to consult a doctor as soon as possible for detailed investigation, and under the doctor’s guidance, carry out active and effective treatment after confirmation of diagnosis.