24-hour urine protein 4000mg belongs to a large amount of proteinuria, mainly consider primary kidney injury and secondary kidney injury caused by different cases have different treatment methods, need to clarify the cause of the disease, regular checkups, it is recommended to go to the regular hospital to avoid delay. 1. Primary kidney injury: elevated urinary protein caused by diseases of the kidney itself, such as glomerulonephritis, pyelonephritis and so on. Commonly used therapeutic drugs include glucocorticoids such as methylprednisolone, cytotoxic drugs such as cyclophosphamide, angiotensin-converting enzyme inhibitors/angiotensin receptor antagonists such as captopril and valsartan, and antibiotics such as levofloxacin. 2. Secondary renal injury: Due to long-term damage of the underlying disease, renal function is also impaired secondary, such as hypertensive nephropathy and diabetic nephropathy. Treatment of primary disease-based antihypertensive and hypoglycemic treatment, commonly used antihypertensive drugs are nifedipine, enalapril, hypoglycemic drugs including acarbose, insulin and so on. In addition, no matter it is primary or secondary kidney injury, patients should pay attention to adequate rest, low-salt, low-fat and high-quality protein diet to avoid aggravating the burden on the kidneys. All of the above drugs need to be taken under the guidance of a physician, the appearance of 24-hour urine protein significantly higher, it is recommended to promptly seek medical treatment under the guidance of a physician to avoid private blind use of medication.