The statement that nephrotic syndrome is incurable once edema occurs is unreliable. Whether or not edema occurs is not necessarily related to the therapeutic effect of nephrotic syndrome, which mainly depends on the renal pathological manifestations and the individual patient’s response to drugs. The clinical symptom of nephrotic syndrome is characterized by edema, and most patients have edema of the lower limbs or the whole body. The degree of edema and proteinuria is also not completely parallel, and there is no obvious correlation with the degree and type of damage of renal pathology. The main factors affecting the therapeutic effect of nephrotic syndrome are the type of pathologic injury and individual differences in response to drugs. For example, the therapeutic effect of microscopic lesion type nephropathy tends to be very good, whereas glomerulopathy with proliferative mesangial capillaries is less responsive to hormonal therapy. The treatment effect is also related to individual differences, some patients will be difficult to get relief. In conclusion, nephrotic syndrome with edema is not untreatable, and it is recommended that patients with nephrotic syndrome should consult the hospital in time, complete the relevant examinations under the guidance of the doctor, and take active treatment.