Safflower oil is effective in relieving knee pain, mainly for treating knee pain caused by wind-cold-dampness, meridian obstruction and blood stasis blockage, and has limited therapeutic effect on knee pain caused by serious meniscus injury, fracture, and degenerative knee joint disease. Safflower oil is a kind of topical patent medicine, which can treat paralysis caused by wind-cold-dampness meridian obstruction and bruises caused by blood stasis obstruction, such as joint pain, swollen joints, blue-red-purple spots, localized stiffness, restricted movement, and so on. Safflower oil consists of clove basil oil, methyl salicylate, ginger camphor oil, cinnamon oil, cinnamaldehyde, citral, and ice chips. A common adverse reaction is contact dermatitis, which is characterized by erythema, swelling, blisters, and papules. Adverse reactions should be discontinued immediately, and if there is no improvement, prompt medical attention is recommended. Safflower oil is prohibited to touch the skin or mucous membrane broken parts, if inadvertently touched, should be immediately washed with cold water. In addition, safflower oil is prohibited for those who are allergic to it and pregnant women, allergy sufferers should use it with caution, and pediatric and elderly patients should use it under the guidance of a physician. When the condition of knee pain can not be relieved on their own, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor for the cause of the appropriate treatment, which will help to improve the knee pain and other uncomfortable symptoms.