Patients with rheumatoid arthritis are able to take Leflunomide for long-term treatment. Leflunomide is a kind of immunosuppressant that inhibits dihydroorotic acid dehydrogenase activity and thus exerts antiproliferative activity, and it can be used to treat rheumatoid arthritis and lupus nephritis in adults. Leflunomide has the effect of improving the condition of rheumatoid arthritis, but the effect of this drug is relatively slow, and it usually needs to be taken for a long period of time. Common adverse drug reactions to Leflunomide include leukopenia, abnormal sensation, and mild increase in blood pressure. Note that patients taking Leflunomide for a long period of time should have regular monitoring of blood counts and liver and kidney functions. Patients who are allergic to the components of Leflunomide drug, patients with severe hypoproteinemia, patients with impaired hepatic function and other patients with contraindications to Leflunomide drug are forbidden to use the drug treatment. Leflunomide should be used strictly under the guidance of a physician, and it is recommended that patients with rheumatoid arthritis go to the rheumatology and immunology department of a regular hospital for detailed consultation.