The next day after the wine regurgitation want to vomit can be oral metoclopramide, benadryl and other drugs to control vomiting symptoms, aluminum sulfate, magnesium aluminum carbonate and other drugs to protect the gastric mucosa. The main chemical composition of wine is ethanol, ethanol can directly damage the gastric mucosa, so that the gastric mucosal epithelial cells necrotic detachment, microvascular endothelial damage, embolism, tissue ischemia and hypoxia necrosis, thus causing gastric mucosal erosion, ulcer formation. This can lead to epigastric distension, discomfort, pain, nausea, loss of appetite and other symptoms. The second day after the wine regurgitation want to vomit can be oral antiemetic drugs to control the vomiting symptoms. The drugs that can be taken orally include dopamine receptor antagonists (domperidone, metoclopramide, etc.), antihistamines (such as diphenhydramine), anticholinergic drugs (such as scopolamine, scopolamine, etc.), and gastric mucosal protection drugs (aluminum thiosulfate, magnesium bicarbonate, etc.). Patients should eat a light diet, mainly fluid and semi-liquid food, avoid eating spicy and stimulating food to aggravate the symptoms. If you have regurgitation and want to vomit discomfort, you should consult a doctor in time, under the guidance of a professional physician for treatment, do not blindly deal with it on your own, so as not to cause adverse consequences.