In the clinic, if the patient is diagnosed with stage A1 duodenal bulb ulcer, he or she is to be treated with esomeprazole triple therapy, because, the main reasons that cause the patient to develop stage A1 duodenal bulb ulcer, are the excessive secretion of gastric acid as well as the infection of Helicobacter pylori. At this time, the patient has to take oral esomeprazole, amoxicillin and clarithromycin for 14 consecutive days, and the exact dosage has to be applied under the supervision of the doctor. The dosage may vary because of individual differences in disease, and endoscopy should be performed 4-6 weeks after discontinuation of the medication, as well as checking for Helicobacter pylori, to observe the healing of the ulcer and the eradication rate of Helicobacter pylori. Usually, esomeprazole has a faster and better inhibition of gastric acid secretion, which can well alleviate the patient’s clinical condition, and amoxicillin and clarithromycin can play a very good bactericidal effect, which can reap good clinical results.