The first thing you should do is to identify the cause of the swelling of the ankle without pain, and then choose physical therapy, medication, surgical treatment and other ways. The causes of ankle swelling without pain are tendon sheath cysts, varicose veins of the lower extremities, nutritional swelling, etc. It is recommended to identify the cause of the disease before treatment, targeted treatment. 1. Tendon sheath cysts: patients with tendon sheath cysts in the ankle area, the cysts may not be accompanied by pain in the early stage, patients can be joint braking, reduce the damage, you can also take drugs such as celecoxib to reduce inflammation, if the cysts recurring episodes can be surgical resection. 2. Varicose veins of the lower limbs: varicose veins of the lower limbs can cause swelling of the ankles, you can take Diosmin tablets, flavonoids vasoactive drugs, to promote venous blood return, reduce edema, if the patient’s lower limb varicose veins are serious, you can take surgical treatment, usually the prognosis is better. 3. Nutritional edema: patients can strengthen the nutritional support, increase the patient’s intake of high quality protein, if the patient has a primary disease should also actively control the primary disease, if necessary, can be injected intravenously albumin. Caused by ankle swelling without pain for more reasons, but also may be associated with old fractures, kidney disease, heart disease and other reasons, if the symptoms persist, it is recommended to promptly go to the hospital to identify the cause of the disease, targeted treatment. The use of drugs need to follow the doctor’s instructions.