Invasion of malignant lymphoma into bone marrow may cause lymphoma cell leukemia. Lymphoma cells can be found in the bone marrow after lymphoma invades the bone marrow. When the lymphoma cells increase and cause symptoms such as enlarged lymph nodes, large liver and spleen, anemia, fever, bleeding, etc., one should be highly alert to lymphoma cell leukemia. The diagnosis is usually confirmed by blood and bone marrow images. It can be treated with chemotherapy, hematopoietic stem cell transplantation, etc. Targeted drug therapy, such as rituximab, etc., can also be used under the guidance of doctors. Lymphoma cell leukemia is usually a manifestation of advanced stage of lymphoma. Once symptoms such as anemia, fever, bleeding, etc. appear, you should go to the hospital in time to find out the cause and under the guidance of the doctor for treatment.