There is generally no treatment for callus on the feet that can go to the root, but it can be treated by general treatment, medication, physical therapy, surgery, etc. to improve the symptoms and reduce recurrence. Callus on the foot is mainly due to the excessive proliferation of the stratum corneum caused by long-term mechanical stimulation (such as pressure and friction). 1. General treatment: usually wear some comfortable shoes, try to avoid wearing high-heeled shoes and hard-soled shoes, pay attention to the protection of foot skin, you can use warm water to soak your feet on a regular basis, soften the stratum corneum and then gently polish the dead skin with pumice stone to reduce the occurrence of callus. 2. Medication: For mild callus, external keratolytic agent can be used, such as salicylic acid ointment, urea ointment and so on. 3. Physical therapy: if necessary, liquid nitrogen cryotherapy can be taken to make the cuticle of the lesion necrosis off, but the treatment should be careful to avoid damage to the surrounding normal tissues. 4. Surgery: if the formation of callus and foot bone deformity has a direct relationship, you can use surgery to correct the foot bone, so as to reduce the local friction and compression, reduce the callus. Suggest that patients with callus, follow the doctor’s instructions reasonable treatment, not blindly self-medication. Usually pay attention to the protection of the foot, to avoid long-term pressure and stimulation.