Nodding-like breathing is also known as sigh-like breathing in clinical practice. The main manifestation is that the patient’s head is tilted back during inhalation and tilted forward during exhalation, repeatedly breathing like sighing or nodding-like changes. Once the patient appears nodding-like breathing is indeed a form of expression before the end of life, which often indicates that the patient’s respiratory muscles are extremely weak, the ability of oxygen and carbon dioxide exchange is extremely weakened, and the patient has severe respiratory failure, which is in a state of extreme hypoxia and ischemia. The patient inhales as much oxygen as possible by nodding-like breathing to maintain the energy needs of the organism. In this case, the patient can be intubated to maintain adequate oxygen intake and to remove as much fluid and sputum as possible from the trachea. Anti-infection treatment is intensified to prolong the patient’s life as much as possible, but overall, the patient’s prognosis is poor.