AIDS is a kind of immunodeficiency disease, can lead to patients with a variety of diseases and different skin lesions, so the characteristics of the AIDS rash according to the cause of the disease, can be manifested as infected skin lesions, non-infected skin lesions and skin tumors. 1. Non-infectious skin damage: the skin lesions are polymorphic, similar to seborrheic dermatitis, ichthyosis, erythematous furuncle, psoriasis, etc., but the condition is usually more serious. In addition, atopic dermatitis photosensitized dermatitis, pityriasis rosea, urticaria erythema multiforme and acne-like lesions can also occur. 2. Infectious lesions: manifested as a variety of pathogens of infection, but the condition is more serious than the average patient. (1) herpes zoster: the scope of involvement is often larger, blisters, blisters, blood blisters, severe pain, very easy to secondary bacterial infection, can cause encephalitis, pneumonia, and even death. (2) Herpes simplex: frequent recurrence, the distribution of lesions is limited or disseminated, manifested as persistent oral, genital, perianal severe herpes, can be a long time and the formation of deep ulcers. (3) warts: can be manifested as common warts, flat warts, infectious molluscum contagiosum, etc. male homosexual patients perianal, rectal often have warts. (4) Fungal infections:Thrush is the earliest symptom of immunodeficiency. (5) Bacterial infections: manifested as folliculitis, multiple skin abscesses, or boils. 3. Skin tumors:including Kaposi’s sarcoma, lymphoma, malignant melanoma, and squamous cell carcinoma. Due to the diversity of skin lesions in AIDS patients, it is often difficult to identify them in the early stages of the disease, so if similar skin lesions appear after high-risk behaviors, they should consult a doctor in a timely manner and follow the doctor’s instructions to use medication.