”Diabetes itself is not scary, but the complications that come with diabetes must be taken seriously.” In clinical practice, we repeatedly warn patients about the dreadfulness of complications, especially chronic complications, which can seriously affect their lives and even threaten their lives. Compared to diabetes itself, the following chronic complications of diabetes (for example) pose a higher risk to patients, so they need to be taken seriously and prevented. 1, diabetic nephropathy Mainly manifested as microangiopathy of the kidney, under the risk factors of hypertension and hyperlipidemia, the arterial wall of the kidney thickens and hardens, the inner diameter of the artery becomes smaller, the viscosity of the blood increases, the blood flow rate decreases, forming a microcirculatory disorder in the kidney. Renal cells become ischemic and hypoxic, and the glomerular pathology changes from intermittent proteinuria or microalbuminuria to persistent proteinuria, nephrogenic edema, decreased renal function, reduced glomerular filtration rate, renal insufficiency, and even uremia, which is one of the causes of death in diabetic patients. Clinical diagnosis mainly relies on the examination of urinary albumin excretion, and the treatment choice of comprehensive treatment based on glucose and blood pressure lowering, and regular follow-up can improve the prognosis of diabetic nephropathy. 2, diabetic retinopathy In diabetic patients, due to the decrease of oxygen dissociation from hemoglobin, the basement membrane of retinal tissue capillaries thickens, and in order to adapt to the microenvironmental changes of ischemia and hypoxia, the production of various pro-angiogenic factors is stimulated, which eventually leads to retinal neovascularization, vitreous blood accumulation, formation of retinal proliferative membrane, and retractive retinal detachment leading to blindness. Patients with diabetic retinopathy may not have obvious clinical symptoms, but regular fundus examinations are extraordinarily important. Patients with sudden blindness or retinal detachment should seek immediate ophthalmology care. Laser photocoagulation is the primary treatment for high-risk proliferative diabetic retinopathy. 3, diabetic foot The diabetic foot is one of the most serious and costly chronic complications of diabetes mellitus. It is caused by abnormal nerves and varying degrees of vasculopathy in the distal lower limbs, resulting in foot infection, ulceration or deep tissue destruction, which can lead to amputation and death in severe cases. For the treatment of diabetic foot, hydrogel debridement and hyperbaric oxygen therapy for foot ulcers when available can help improve the inflammation and microcirculatory condition of the wound and promote wound healing. In conclusion, once suffering from diabetes, patients should pay attention to controlling blood glucose to avoid letting it develop to the stage of complications, which can seriously reduce the quality of life and pose a threat to health and even life. References [1] Ye WJ, Cao JF. Clinical analysis of diabetes mellitus complications [J]. New World of Diabetes, 2015(14):93-94. [2] Liu E N. Analysis of diagnosis and treatment of diabetic complications [J]. Health for All (Academic Edition), 2014(1):82-82. [3] Zheng Xiaowei, Chu Jianping. Homocysteine and complications of type 2 diabetes mellitus[J]. Clinical meta-analysis, 2014(11):1316-1.